Highly experienced staff
Custom Services
Fast turn-around times
Fully cGMP/GLP compliant

We have business alliances with Pacific BioLabs (Formerly Northview Biosciences), High Throughput Development, Murigenics and others local experts to provide streamlined in vivo testing with bioanalytical support.

Equipment

• ABI Q-STAR Pulsar i mass spectrometer with ESI and APCI sources
• SCIEX API 3000 triple quadrupole mass spectrometer with ESI and APCI sources
• Varian 1200 LC/MS/MS system
• Shimadzu VP modular HPLC system with high capacity, microplate compatible autosampler
• Gilson modular HPLC with high capacity, microplate compatible autosampler
• Eldex MicroPro binary syringe pump for capillary HPLC

LC/MS/MS Services Include

Bioanalytical
From plasma, blood pellets and tissues Analysis of parent stability, metabolite, profiling and structural elucidation Rapid-throughput Microplate sample processing Method development and FDA validation Support early pre-clinical screening through clinical trials
Calibration Curve of Discovery Compound Over 3 logs in Concentration with an LLOQ of 1 ng/mL (Courtesty of Genesoft, Inc.)
Biotechnology
Proteomics support Protein identification at the femtomole level Peptide mapping with sequence verification Identification and monitoring of peptide/protein modifications Identification, quantitation and structure elucidation of process impurities or degradation products Protein MW determination
Chromatography, Identification (MS) and Sequence (MS/MS) of low abundance peptide (577.4 m/z) depicted by arrow
Pharmaceutical
Characterization of synthesis products and complex mixtures Identification, quantitation and structure elucidation of syntheses or process impurities and degradation products